Assistant Professor of Computational Biology
Investigator, Heritage Medical Research Institute
The Thomson Lab is applying quantitative experimental and modeling approaches to gain programmatic control over cellular differentiation. It is developing mathematical models to ask how cellular regulatory networks generate the vast diversity of cell-types that exists in the human body. The lab is applying models to engineer and rewire cellular physiology and to synthesize new types of cells that do not exist in nature. They are also developing simplified cellular systems in which physical models can be applied to control the geometry and morphology of different cell types. The lab uses a combination of approaches including mathematical modeling, machine learning, statistical analysis of high-throughput gene expression data, and single cell RNA sequencing experiments.